排序方式: 共有175条查询结果,搜索用时 296 毫秒
51.
Oliviero G Amato J Borbone N D'Errico S Galeone A Mayol L Haider S Olubiyi O Hoorelbeke B Balzarini J Piccialli G 《Chemical communications (Cambridge, England)》2010,46(47):8971-8973
The biophysical and biological properties of unprecedented anti-HIV aptamers are presented. The most active aptamer (1L) shows a significant affinity to the HIV protein gp120. 相似文献
52.
Pastorin G Marchesan S Hoebeke J Da Ros T Ehret-Sabatier L Briand JP Prato M Bianco A 《Organic & biomolecular chemistry》2006,4(13):2556-2562
Four different regioisomers of cationic bis-N,N-dimethylfulleropyrrolidinium salts have been prepared and evaluated as inhibitors of the enzymatic activity of acetylcholinesterase. These fullerene-based derivatives were found to be noncompetitive inhibitors of acetylthiocholine hydrolysis. Molecular modelling was used to describe the possible interactions between the fullerene cage and the amino acids surrounding the cavity of the enzyme. The cationic C(60) derivatives used in this study represent a new class of molecules potentially able to modulate the enzymatic activity of acetylcholinesterase. 相似文献
53.
Vincenzo Piccialli Sabrina Zaccaria Giorgia Oliviero Akseli Hemminki Valentina Romano Roberto Centore 《Tetrahedron》2010,66(48):9370-9378
Four novel C30 polyether bis-spiroketals, displaying selective inhibition of the BT474 breast-derived cancer cell line, have been obtained from squalene through an unprecedented one-step, RuO4-catalysed, cascade process characterised by a tandem oxidative pentacyclization/double oxidative spiroketalization sequence. Preliminary studies indicate that the Ru-mediated spiroketalization steps proceed with retention of configuration at the forming spirocentres. A similarity with the oxidative behaviour of PCC has been disclosed. 相似文献
54.
Moro S Deflorian F Spalluto G Pastorin G Cacciari B Kim SK Jacobson KA 《Chemical communications (Cambridge, England)》2003,(24):2949-2956
We review our recent work on adenosine receptors, a family of GPCRs; focusing our attention on A3 adenosine receptor, we have demonstrated that the reciprocal integration of different theoretical and experimental disciplines can be very useful for the successful protein-based design of new, potent and selective receptor ligands. 相似文献
55.
Giorgia Miolo Vittorio Lucchini Paolo Rodighiero Francesco Dall'Acqua Sergio Caffieril 《Photochemistry and photobiology》1994,59(3):277-283
The isolation and characterization of photocycloadducts with pyrimidine bases from DNA samples irradiated (365 nm) in the presence of four 4',5'-substituted methylangelicins was performed. All these furocoumarins yielded mainly the cis-syn furan-side cycloadduct with thymine. For 4',5'-dimethyl-, 5,4',5'-trimethyl- and 6,4',5'-trimethylangelicin this adduct was accompanied by two pyrone-side adducts ( cis-syn and cis-anti ), whereas the 4,4',5'-trimethyl derivative gave the furan-side adduct with cytosine.
The characterization of the regio- and stereochemistry of the adducts was accomplished by1 H NOE (nuclear Overhauser effect) and 1 H-13 C HMBC (heteronuclear multiple-bond connectivity) spectroscopies.
The formation of different cycloadducts in DNA by the various derivatives highlights the role of the methyl groups in determining the regio- and stereochemistry of the cycloaddition. 相似文献
The characterization of the regio- and stereochemistry of the adducts was accomplished by
The formation of different cycloadducts in DNA by the various derivatives highlights the role of the methyl groups in determining the regio- and stereochemistry of the cycloaddition. 相似文献
56.
Cocchi M Foca G Marchetti A Sighinolfi S Lorenzo T Ulrici A 《Annali di chimica》2005,95(9-10):657-666
Different kinds of bread, stored at constant temperature and at controlled humidity conditions for a week since their manufacturing date, were analysed by Attenuated Total Reflectance-Fourier Transform InfraRed (ATR-FTIR) spectroscopy. The collected spectra were processed by Principal Component Analysis (PCA), in order to evaluate the changes occurring during bread ageing. For the sake of comparison, the 1060-950 cm spectral window has been also investigated by curve-fitting methods. It was observed that the first PC increases monotonically with ageing of samples. Furthermore, the more influential variables on PC1 correspond to spectral regions where are located stretching and bending bands, which are mainly attributed to typical starch bonds vibrations. 相似文献
57.
Alessandro Ulrici Marina Cocchi Giorgia Foca Matteo Manfredini Daniela Manzini Andrea Marchetti Simona Sighinolfi Lorenzo Tassi 《Journal of solution chemistry》2006,35(2):139-159
In this paper, the temperature and composition dependencies of the volumetric behavior are studied for the ethane-1,2-diol
+ 2-methoxyethanol + 1,2-dimethoxyethane + water quaternary system. Density data were collected at different temperatures
ranging from −10 to 80 ∘C and at atmospheric pressure over the whole composition range, 0≤ xi(i = 1, 2, 3, 4)≤ 1. Moreover, we also made use of the results on the six binary (ij) and four ternary (kij) subsystems studied previously. The excess molar volume (VE) data have been fitted to an equation derived from the well-known Redlich–Kister equation and some interesting correlations
were found. Furthermore, in order to represent in an effective way the behavior of the VE = VE(xi) function (and of the derived partial molar quantities) in the quaternary domain, a new algorithm has been developed, which
gives 3D plots where the dependent function is depicted by means of “colored slices” of the tetrahedron corresponding to the
investigated composition quaternary domain. 相似文献
58.
The improved resolution power of electrophoretic fractionation of DNA in a wide range of molecular masses is demonstrated using an "up and down" application of voltage gradient gel electrophoresis (VGGE). This application also allows separation of different DNA fragments which are poorly fractionated in conventional electrophoresis. 相似文献
59.
Dr. Priyankar Paira Mun Juinn Chow Gopalakrishnan Venkatesan Vamsi Krishna Kosaraju Dr. Siew Lee Cheong Karl‐Norbert Klotz Dr. Wee Han Ang Assoc.Prof. Giorgia Pastorin 《Chemistry (Weinheim an der Bergstrasse, Germany)》2013,19(25):8321-8330
Human A3 adenosine receptor (hA3AR) is a membrane‐bound G protein‐coupled receptor implicated in a number of severe pathological conditions, including cancer, in which it acts as a potential therapeutic target. To derive structure–activity relationships on pyrazolo–triazolo–pyrimidine (PTP)‐based A3AR antagonists, we developed a new class of organometallic inhibitors through replacement of the triazolo moiety with an organoruthenium fragment. The objective was to introduce by design structural diversity into the PTP scaffold in order to tune their binding efficacy toward the target receptor. These novel organoruthenium antagonists displayed good aquatic stability and moderate binding affinity toward the hA3 receptor in the low micromolar range. The assembly of these complexes through a template‐driven approach with selective ligand replacement at the metal center to control their steric and receptor‐binding properties is discussed. 相似文献
60.
Preparation of Constrained Unnatural Aromatic Amino Acids via Unsaturated Diketopiperazine Intermediate 下载免费PDF全文
Adriano Mollica Roberto Costante Sako Mirzaie Simone Carradori Giorgia Macedonio Azzurra Stefanucci Ettore Novellino 《Journal of heterocyclic chemistry》2016,53(6):2106-2110
Unnatural aromatic amino acids are useful tools in drug discovery, since their insertion in bioactive peptide sequences can change the side chains spatial orientation, the backbone conformation and above all, their bioactivity. In this communication, we propose a straightforward method to synthesize 2′,6′‐dimethyl‐tyrosine and 2′,6′‐dimehylphenyl‐alanine derivatives as handling building blocks for peptide synthesis via unsaturated diketopiperazine (DKP) intermediate. 相似文献